The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2020
Filed:
Sep. 11, 2018
Applicant:
Nono Inc., Toronto, Ontario, CA;
Inventor:
Jonathan David Garman, Thornhill, CA;
Assignee:
NoNO Inc., Toronto, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/10 (2006.01); C07K 7/08 (2006.01); A61K 38/16 (2006.01); A61K 9/19 (2006.01); C07K 14/705 (2006.01); C07K 7/06 (2006.01); C07K 19/00 (2006.01); C07K 14/16 (2006.01); A61K 9/00 (2006.01); A61K 47/12 (2006.01); A61K 47/18 (2017.01); A61K 47/26 (2006.01); C07K 14/005 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/162 (2013.01); A61K 9/0019 (2013.01); A61K 9/19 (2013.01); A61K 38/10 (2013.01); A61K 47/12 (2013.01); A61K 47/183 (2013.01); A61K 47/26 (2013.01); C07K 7/06 (2013.01); C07K 7/08 (2013.01); C07K 14/005 (2013.01); C07K 14/16 (2013.01); C07K 14/163 (2013.01); C07K 14/705 (2013.01); C07K 19/00 (2013.01); A61K 38/00 (2013.01); C12N 2740/16322 (2013.01);
Abstract
The present invention provides lyophilized formulations of active agents, particularly of TAT-NR2B9c, as chloride salts. TAT-NR2B9c has shown promise for treating stroke, aneurysm, subarachnoid hemorrhage and other neurological or neurotraumatic conditions. The chloride salt of TAT-NR2B9c shows improved stability compared with the acetate salt form of prior formulations. Formulations of the chloride salt of TAT-NR2B9c are stable at ambient temperature thus facilitating maintenance of supplies of such a formulation in ambulances for administration at the scene of illness or accident or in transit to a hospital.