The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2020
Filed:
Jun. 09, 2016
President and Fellows of Harvard College, Cambridge, MA (US);
Charité Universitätsmedizin Berlin, Berlin, DE;
Pascal Joly, Boston, MA (US);
Georg N. Duda, Berlin, DE;
Thomas Schaus, Boston, MA (US);
Anke Dienelt, Berlin, DE;
Andrea Sass, Berlin, DE;
David J. Mooney, Sudbury, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
CHARITÉUNIVERSITÄTSMEDIZIN BERLIN, Berlin, DE;
Abstract
The present invention is directed to a device for enriching cells with a cell surface marker, comprising an aptamer suitable for specifically binding the cell surface marker, and beads coupled thereto, wherein the aptamer is coupled to the beads in a manner that allows for release of cells expressing the cell surface marker, in the absence of a chemical agent, and production of a cell population enriched for cells expressing the cell surface marker, substantially free of beads and aptamer. Kits comprising the device or components thereof, and methods of cell enrichment, are also provided. In exemplary embodiments, the device contains an aptamer that specifically binds CD31.