The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2020
Filed:
Jan. 13, 2015
Applicants:
The General Hospital Corporation, Boston, MA (US);
Donald B. Bloch, Boston, MA (US);
Inventors:
Warren M. Zapol, Cambridge, MA (US);
Akito Nakagawa, Cambridge, MA (US);
Francine E. Lui, Toronto, CA;
Revital Freedman, Brookline, MA (US);
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4196 (2006.01); A61K 35/18 (2015.01); A61K 31/4155 (2006.01); A61K 31/4178 (2006.01); A61K 31/4192 (2006.01); A61K 31/427 (2006.01); A61K 31/433 (2006.01); A61K 31/4015 (2006.01); A61K 31/42 (2006.01); A61K 31/352 (2006.01); A61K 31/525 (2006.01); A61K 31/198 (2006.01); A61K 31/17 (2006.01); A61K 31/167 (2006.01); A61K 33/30 (2006.01); A61K 31/381 (2006.01); A61K 31/41 (2006.01); A61K 31/422 (2006.01); A61K 31/444 (2006.01); C07D 231/18 (2006.01); C07D 233/86 (2006.01); C07D 249/04 (2006.01); C07D 249/12 (2006.01); C07D 249/14 (2006.01); C07D 257/04 (2006.01); C07D 261/10 (2006.01); C07D 277/36 (2006.01); C07D 285/08 (2006.01); C07D 285/125 (2006.01); C07D 285/135 (2006.01); C07D 333/40 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C12N 5/078 (2010.01);
U.S. Cl.
CPC ...
A61K 35/18 (2013.01); A61K 31/167 (2013.01); A61K 31/17 (2013.01); A61K 31/198 (2013.01); A61K 31/352 (2013.01); A61K 31/381 (2013.01); A61K 31/4015 (2013.01); A61K 31/41 (2013.01); A61K 31/4155 (2013.01); A61K 31/4178 (2013.01); A61K 31/4192 (2013.01); A61K 31/4196 (2013.01); A61K 31/42 (2013.01); A61K 31/422 (2013.01); A61K 31/427 (2013.01); A61K 31/433 (2013.01); A61K 31/444 (2013.01); A61K 31/525 (2013.01); A61K 33/30 (2013.01); C07D 231/18 (2013.01); C07D 233/86 (2013.01); C07D 249/04 (2013.01); C07D 249/12 (2013.01); C07D 249/14 (2013.01); C07D 257/04 (2013.01); C07D 261/10 (2013.01); C07D 277/36 (2013.01); C07D 285/08 (2013.01); C07D 285/125 (2013.01); C07D 285/135 (2013.01); C07D 333/40 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C12N 5/0641 (2013.01);
Abstract
This invention relates to compounds of Formula I: (Formula I), and pharmaceutically acceptable salt thereof, which are allosteric effectors that increase the oxygen-being affinity of hemoglobin, which are useful in the treatment of sickle cell disease, high altitude tissue hypoxia, and other conditions.