The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 01, 2020

Filed:

Sep. 17, 2019
Applicant:

Kempharm, Inc., Celebration, FL (US);

Inventors:

Travis Mickle, Celebration, FL (US);

Sven Guenther, Coralville, IA (US);

Sanjib Bera, Blacksburg, VA (US);

Jaroslaw Kanski, Blacksburg, VA (US);

Andrea Martin, Fincastle, VA (US);

Assignee:

KemPharm, Inc., Celebration, FL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 489/08 (2006.01); A61K 31/485 (2006.01); A61K 47/54 (2017.01); A61K 47/55 (2017.01); C07D 221/28 (2006.01);
U.S. Cl.
CPC ...
A61K 31/485 (2013.01); A61K 47/542 (2017.08); A61K 47/545 (2017.08); A61K 47/55 (2017.08); C07D 221/28 (2013.01); C07D 489/08 (2013.01);
Abstract

The presently described technology provides compositions comprising aryl carboxylic acids and, for example NSAIDs, chemically conjugated to oxymorphone (4,5-α-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one) to form novel prodrugs/compositions of oxymorphone, including benzoates, salicylates, propionates, fenamates, and acetates, which have a decreased potential for abuse of oxymorphone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.


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