The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 25, 2020
Filed:
Apr. 18, 2014
Applicant:
The Johns Hopkins University, Baltimore, MD (US);
Inventors:
Amnon Bar-Shir, Baltimore, MD (US);
Jeff W. M. Bulte, Fulton, MD (US);
Michael T. McMahon, Columbia, MD (US);
Assignee:
The Johns Hopkins University, Baltimore, MD (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 24/08 (2006.01); A61B 5/055 (2006.01); A61K 49/10 (2006.01); G01R 33/485 (2006.01); G01R 33/56 (2006.01); C07C 229/40 (2006.01); G01R 33/46 (2006.01); G01R 33/465 (2006.01); G01R 33/28 (2006.01);
U.S. Cl.
CPC ...
G01N 24/08 (2013.01); A61B 5/055 (2013.01); A61K 49/10 (2013.01); C07C 229/40 (2013.01); G01R 33/485 (2013.01); G01R 33/5601 (2013.01); G01R 33/5605 (2013.01); G01R 33/281 (2013.01); G01R 33/465 (2013.01); G01R 33/4608 (2013.01);
Abstract
The invention features a novel non-invasive approach for imaging, detecting and/or sensing metal ions with improved sensitivity and specificity in a biological sample or tissue. In certain embodiments, the invention provides a MR contrast-based approach for imaging, detecting and/or sensing metal ions in the biological sample/tissue containing various background ions by usingF-based chemical exchange saturation transfer (CEST) technique.