The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 25, 2020

Filed:

Feb. 14, 2017
Applicant:

Stichting Het Nederlands Kanker Instituut-antoni Van Leeuwenhoek Ziekenhuis, Amsterdam, NL;

Inventors:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 21/31 (2006.01); G01N 33/02 (2006.01); G01N 33/12 (2006.01); G01N 21/47 (2006.01); G01N 21/49 (2006.01); A61B 5/00 (2006.01); G01J 3/42 (2006.01); G01J 3/28 (2006.01); G01J 3/12 (2006.01);
U.S. Cl.
CPC ...
G01N 21/314 (2013.01); A61B 5/0075 (2013.01); A61B 5/441 (2013.01); A61B 5/4869 (2013.01); A61B 5/4872 (2013.01); A61B 5/4875 (2013.01); G01J 3/2823 (2013.01); G01J 3/42 (2013.01); G01N 21/4738 (2013.01); G01N 21/4795 (2013.01); G01N 21/49 (2013.01); G01N 33/02 (2013.01); G01N 33/025 (2013.01); G01N 33/12 (2013.01); A61B 5/0077 (2013.01); A61B 5/0091 (2013.01); A61B 5/7239 (2013.01); A61B 2505/05 (2013.01); A61B 2576/00 (2013.01); G01J 2003/1213 (2013.01); G01J 2003/1221 (2013.01); G01J 2003/2826 (2013.01); G01J 2003/425 (2013.01); G01N 2021/3133 (2013.01); G01N 2021/3137 (2013.01); G01N 2021/3174 (2013.01); G01N 2201/103 (2013.01); G01N 2201/1053 (2013.01);
Abstract

In a method and apparatus, a property of an optically diffuse medium including a first optical absorber having a first concentration and a second optical absorber having a second concentration is determined. A surface area of the medium is imaged at multiple wavelengths around an isosbestic wavelength of the first absorber and the second absorber. A reflectance spectrum of the medium at the surface area at the multiple wavelengths is determined. A derivative of the determined reflectance spectrum around the isosbestic wavelength is determined. From the derivative, a concentration ratio of the first concentration and the second concentration is estimated.


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