The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 25, 2020
Filed:
Jun. 25, 2018
Applicant:
Cedars-sinai Medical Center, Los Angeles, CA (US);
Inventor:
Lali K. Medina-Kauwe, Porter Ranch, CA (US);
Assignee:
CEDARS-SINAI MEDICAL CENTER, Los Angeles, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61P 35/00 (2006.01); C40B 10/00 (2006.01); C07K 1/00 (2006.01); C07K 14/00 (2006.01); C07K 17/00 (2006.01); C12N 15/10 (2006.01); C12N 15/87 (2006.01); C07K 14/005 (2006.01); A61K 47/64 (2017.01);
U.S. Cl.
CPC ...
C12N 15/1058 (2013.01); A61K 47/645 (2017.08); C07K 14/005 (2013.01); C12N 15/1037 (2013.01); C12N 15/87 (2013.01); C12N 2710/10322 (2013.01); C12N 2710/10341 (2013.01);
Abstract
The invention relates to methods for isolating traffic-enhancing mutants of drug delivery proteins. In one embodiment, the invention provides a carrier for delivering a therapeutic agent to an organelle, comprising a polypeptide encoded by a mutant penton base gene. In another embodiment, the invention provides a method of enhancing trafficking to a cell by administering a composition comprising a penton base (PB) protein with one or more mutations that enhance cellular entry.