The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 25, 2020

Filed:

Mar. 14, 2014
Applicants:

Amgen Research (Munich) Gmbh, Munich, DE;

Boehringer Ingelheim International Gmbh, Ingelheim am Rhein, DE;

Inventors:

Peter Kufer, Munich, DE;

Tobias Raum, Munich, DE;

Patrick Hoffmann, Munich, DE;

Roman Kischel, Munich, DE;

Ralf Lutterbuese, Munich, DE;

Doris Rau, Munich, DE;

Paul Adam, Ingelheim am Rhein, DE;

Eric Borges, Ingelheim am Rhein, DE;

Barbara Hebeis, Ingelheim am Rhein, DE;

Susanne Hipp, Ingelheim am Rhein, DE;

Assignee:

Amgen Inc., Thousand Oaks, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); C07K 16/46 (2006.01); A61K 39/395 (2006.01); C07K 14/705 (2006.01); C07K 14/715 (2006.01); C07K 14/725 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2878 (2013.01); A61K 39/3955 (2013.01); C07K 16/2809 (2013.01); C07K 16/2896 (2013.01); C07K 16/468 (2013.01); A61K 2039/505 (2013.01); C07K 2317/31 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2319/20 (2013.01); C07K 2319/21 (2013.01); C07K 2319/74 (2013.01);
Abstract

The present invention relates to a binding molecule comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope clusters of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with the vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of the binding molecule and a kit comprising the binding molecule.


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