The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 25, 2020
Filed:
Jun. 12, 2017
Academia Sinica, Taipei, TW;
An-Suei Yang, Emeryville, CA (US);
Hong-Sen Chen, Taipei, TW;
Chung-Ming Yu, Taipei, TW;
Shin-Chen Hou, Taipei, TW;
Wei-Ying Kuo, Taipei, TW;
Yi-Kai Chiu, Taipei, TW;
Yueh-Liang Tsou, Taipei, TW;
Hung-Ju Hsu, Taipei, TW;
Hwei-Jiung Wang, Taipei, TW;
Shih-Hsien Chuang, New Taipei, TW;
Chao-Pin Lee, New Taipei, TW;
ACADEMIA SINICA, Taipei, TW;
Abstract
Disclosed herein are methods for high-throughput screening of a functional antibody fragment for an immunoconjugate that targets a protein antigen. The method combines a phage-displayed synthetic antibody library and high-throughput cytotoxicity screening of non-covalently assembled immunotoxins or cytotoxic drug to identify highly functional synthetic antibody fragments for delivering toxin payloads.