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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10752673 B1

PDFFull Text
Date of Patent:
Aug. 25, 2020

Filed:

Jun. 12, 2017

High-throughput screening of functional antibody fragments, immunoconjugate comprising the same, and adaptor-drug conjugate for screening

Applicant:

Academia Sinica, Taipei, TW;

Inventors:

An-Suei Yang, Emeryville, CA (US);

Hong-Sen Chen, Taipei, TW;

Chung-Ming Yu, Taipei, TW;

Shin-Chen Hou, Taipei, TW;

Wei-Ying Kuo, Taipei, TW;

Yi-Kai Chiu, Taipei, TW;

Yueh-Liang Tsou, Taipei, TW;

Hung-Ju Hsu, Taipei, TW;

Hwei-Jiung Wang, Taipei, TW;

Shih-Hsien Chuang, New Taipei, TW;

Chao-Pin Lee, New Taipei, TW;

Assignee:

ACADEMIA SINICA, Taipei, TW;

Attorney:
Primary Examiner:

Rodney P Swartz

Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 39/00 (2006.01); A61K 39/02 (2006.01); C07K 16/00 (2006.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01); C07K 16/32 (2006.01); C07K 19/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/005 (2013.01); A61K 47/6817 (2017.08); A61K 47/6829 (2017.08); A61K 47/6851 (2017.08); A61P 35/00 (2018.01); C07K 16/32 (2013.01); C07K 19/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/10 (2013.01); C07K 2317/35 (2013.01); C07K 2317/55 (2013.01); C07K 2317/622 (2013.01); C07K 2317/73 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01); C07K 2319/04 (2013.01); C07K 2319/55 (2013.01);
Abstract

Disclosed herein are methods for high-throughput screening of a functional antibody fragment for an immunoconjugate that targets a protein antigen. The method combines a phage-displayed synthetic antibody library and high-throughput cytotoxicity screening of non-covalently assembled immunotoxins or cytotoxic drug to identify highly functional synthetic antibody fragments for delivering toxin payloads.

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Quick Actions:

Yang, An-Suei. (2020). High-throughput screening of functional antibody fragments, immunoconjugate comprising the same, and adaptor-drug conjugate for screening (U.S. Patent No. 10752673). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10752673

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