The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 25, 2020
Filed:
Jul. 24, 2015
Theravectys, Paris, FR;
Institut Curie, Paris, FR;
Centre National DE LA Recherche Scientifique, Paris, FR;
Universite Pierre ET Marie Curie, Paris, FR;
Institut National DE LA Sante ET DE LA Recherche Medicale (Inserm), Paris, FR;
Sophie Agaugue, Paris, FR;
Lorenzo Tibaldi, Paris, FR;
Klervi Even-Desrumaux, Antony, FR;
Dmitry Trubetskoy, Arcueil, FR;
Franck Perez, Paris, FR;
Sebastian Amigorena, Paris, FR;
Cécile Bauche, Paris, FR;
Theravectys, Paris, FR;
Institut Curie, Paris, FR;
Centre National de la Recherche Scientifique, Paris, FR;
Sorbonne Universite, Paris, FR;
Institut National de la Sante et de la Recherche Medicale (INSERM), Paris, FR;
Abstract
The invention relates to the regulated expression of a chimeric antigen receptor (CAR) within a lentiviral vector. The CAR comprises a hook-binding domain that interacts with a hook, preferably encoded by the same lentiviral vector, which prevents proper processing and release of the CAR to the cell membrane. The invention encompasses vectors, methods of making the vectors, and methods of using them, including medicinal uses. The vectors can be used for administration to humans to induce immune responses and to treat cancers and tumors.