The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 25, 2020

Filed:

Mar. 13, 2018
Applicant:

Daiichi Sankyo Company, Limited, Chuo-ku, Tokyo, JP;

Inventors:

Manoj Kumar Khera, Chuo-ku, JP;

Naresh Chintaman Dumbre, Chuo-ku, JP;

Pasha Khan, Chuo-ku, JP;

Assignee:

Daiichi Sankyo Company, Limited, Chuo-ku, Tokyo, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07F 9/6558 (2006.01); A61P 31/04 (2006.01);
U.S. Cl.
CPC ...
C07F 9/65583 (2013.01); A61P 31/04 (2018.01);
Abstract

There is a need for a new antibiotic having a novel mechanism of action, which exhibits strong antibacterial activity not only against sensitive bacteria, but also against resistant bacteria thereof, and at the same time possess excellent solubility and safety profile amenable to human use. As a result of intensive research, the present inventors have found that N-phosphonoxymethyl prodrugs of hydroxyalkyl thiadiazole derivatives represented by general formula (I), a regioisomer, a stereoisomer, or a pharmaceutically acceptable salt thereof possess excellent solubility and safety profile for use in human for the treatment of bacterial infectious diseases.


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