The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 25, 2020

Filed:

Jun. 28, 2018
Applicants:

Rutgers, the State University of New Jersey, New Brunswick, NJ (US);

Lehigh University, Bethlehem, PA (US);

Inventors:

Jeffrey D. Laskin, Piscataway, NJ (US);

Diane E. Heck, Rumson, NJ (US);

Carl J. Lacey, Schnecksville, PA (US);

Ned D. Heindel, Easton, PA (US);

Sherri C. Young, Bloomsbury, NJ (US);

Assignees:

LEHIGH UNIVERSITY, Bethlehem, PA (US);

RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, New Brunswick, NJ (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 207/16 (2006.01); C07D 209/18 (2006.01); A61K 47/54 (2017.01); A61K 47/55 (2017.01);
U.S. Cl.
CPC ...
C07D 207/16 (2013.01); A61K 47/542 (2017.08); A61K 47/543 (2017.08); A61K 47/55 (2017.08); C07D 209/18 (2013.01);
Abstract

Augmented or synergized anti-inflammatory constructs are disclosed including anti-inflammatory amino acids covalently conjugated with other anti-inflammatory molecules such as nonsteroidal anti-inflammatory drugs, vanilloids and ketone bodies. Further conjugation with a choline bioisostere or an additional anti-inflammatory moiety further augments the anti-inflammatory activity.


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