The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 25, 2020
Filed:
Mar. 20, 2019
Applicant:
Biotronik Ag, Buelach, CH;
Inventors:
Ronald E. Betts, La Jolla, CA (US);
John Dang Nguyen, San Diego, CA (US);
Beatris Flores, San Diego, CA (US);
Assignee:
Biotronik AG, Buelach, CH;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61L 31/16 (2006.01); A61L 31/10 (2006.01); A61K 47/46 (2006.01); A61K 47/26 (2006.01); A61K 38/17 (2006.01); A61K 38/16 (2006.01); A61K 36/68 (2006.01); A61K 31/685 (2006.01); C07D 498/18 (2006.01); C08L 67/04 (2006.01);
U.S. Cl.
CPC ...
A61L 31/16 (2013.01); A61K 31/685 (2013.01); A61K 36/68 (2013.01); A61K 38/168 (2013.01); A61K 38/1709 (2013.01); A61K 47/26 (2013.01); A61K 47/46 (2013.01); A61L 31/10 (2013.01); C07D 498/18 (2013.01); C08L 67/04 (2013.01); A61L 2300/416 (2013.01); A61L 2300/606 (2013.01); A61L 2300/608 (2013.01);
Abstract
A new class of rapamycin 40-O-cyclic hydrocarbon esters is disclosed. The 40-O position of the rapamycin ester has the form 40-O—R, where R is C(O)—(CH)—X, n is 0, 1 or 2, and X is a cyclic hydrocarbon having 3-8 carbons, optionally containing one or more unsaturated bonds, and one or more linear (CH)) and/or cyclic (X) carbon atoms may have an OH or halide group. Also disclosed are therapeutic compositions and methods that employ the novel analogs.