The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 25, 2020
Filed:
Sep. 07, 2018
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Michael T. Migawa, Carlsbad, CA (US);
Jinghua Yu, San Marcos, CA (US);
W. Brad Wan, Fallbrook, CA (US);
Sayten P. Patel, Mundelein, IL (US);
Guillermo Vasquez, Oceanside, CA (US);
Garth A. Kinberger, San Diego, CA (US);
Thazha P. Prakash, Carlsbad, CA (US);
Punit P. Seth, Carlsbad, CA (US);
Eric E. Swayze, Encinitas, CA (US);
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Abstract
Provided herein are improved methods for the synthesis of reactive conjugate clusters and intermediates used in such methods. In particular, improvements are provided that enhance the synthesis of reactive conjugate clusters by reducing the number of synthetic steps required. The reactive conjugate clusters prepared using the improved methods don't include any transacylation impurities that are formed using existing methods. The improved methods also provide an increase in overall yield and a cost benefit over existing methods.