The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 25, 2020
Filed:
Nov. 15, 2019
Applicant:
The Children's Medical Center Corporation, Boston, MA (US);
Inventor:
Paolo Fiorina, Boston, MA (US);
Assignee:
The Children's Medical Center Corporation, Boston, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/28 (2015.01); C07K 16/28 (2006.01); C12N 5/0789 (2010.01); A61P 3/10 (2006.01); C07K 14/705 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/28 (2013.01); A61P 3/10 (2018.01); C07K 14/70532 (2013.01); C07K 16/2818 (2013.01); C12N 5/0647 (2013.01); A61K 2039/505 (2013.01); C07K 2317/75 (2013.01); C12N 2500/90 (2013.01); C12N 2501/113 (2013.01); C12N 2501/125 (2013.01); C12N 2501/145 (2013.01); C12N 2501/17 (2013.01); C12N 2501/91 (2013.01); C12N 2501/999 (2013.01); C12N 2510/00 (2013.01);
Abstract
Embodiments disclosed here provide engineered modified hematopoietic stem cells (HSCs), artificially prostaglandin E2 (PGE)-stimulated HSCs, compositions comprising these HSCs, methods of using these modified HSCs for treating autoimmune diseases and disorders and for suppressing the immune system. In particular, the engineered modified HSCs or PGE-stimulated HSCs express the surface marker, programmed cell death-1 ligand 1 (PD-L1).