The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 25, 2020
Filed:
May. 27, 2019
Georgia State University Research Foundation, Inc., Atlanta, GA (US);
Binghe Wang, Marietta, GA (US);
Danzhu Wang, Atlanta, GA (US);
Xingyue Ji, Atlanta, GA (US);
Alexander Draganov, Atlanta, GA (US);
Chaofeng Dai, Atlanta, GA (US);
Krishna Damera, Smyrna, GA (US);
Didier Merlin, Decatur, GA (US);
Emilie Viennois, Atlanta, GA (US);
Yueqin Zheng, Atlanta, GA (US);
GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC., Atlanta, GA (US);
Abstract
Carbon monoxide-releasing organic molecules are described herein. The molecules can be synthesized prior to administration (e.g., ex vivo) or formed in vivo. In those embodiments where the molecules are formed in vivo, reactants are administered under physiological conditions and undergo a cycloaddition reaction to form a product which releases carbon monoxide. In applying such reactions for therapeutic applications in vivo, the cycloaddition and CO release typically occur only under near-physiological or physiological conditions. For example, in some embodiments, the cycloaddition reaction and/or release of carbon monoxide occur at a temperature of about 37° C. and pH of about 7.4. Pharmaceutical compositions and methods for release carbon monoxide are also described.