The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 18, 2020
Filed:
Sep. 22, 2017
Millennium Pharmaceuticals, Inc., Cambridge, MA (US);
Ian Armitage, Medford, MA (US);
Eric L. Elliott, Brighton, MA (US);
Marianne Langston, North Andover, MA (US);
Steven P. Langston, North Andover, MA (US);
Quentin J. McCubbin, Belmont, MA (US);
Hiro Mizutani, Cambridge, MA (US);
Matthew Stirling, Boston, MA (US);
Lei Zhu, Bedford, MA (US);
Millennium Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
The present invention provides processes and synthetic intermediate (Ia) for the synthesis of 4-substituted ((1S, 2S, 4R)-2-hydroxy-4-{7H-pyrrolo[2,3-d]pyrimidin-7-yl}cyclopentyl)methyl sulfamates. These sulfamate compounds are E1 activating enzyme inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with E1 activity.