The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 18, 2020
Filed:
Nov. 06, 2019
Applicant:
Cervello Therapeutics Llc, Malvern, PA (US);
Inventors:
Matthew Randolph Lee, Del Mar, CA (US);
Anthony Joseph Varano, Jr., Berwyn, PA (US);
Assignee:
Cervello Therapeutics, LLC., Malvern, PA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4725 (2006.01); A61K 31/502 (2006.01); C07D 217/24 (2006.01); C07D 237/32 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 471/04 (2013.01);
Abstract
The present invention relates to indoline-based compounds that inhibit Rho-associated protein kinase (ROCK) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.