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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10745377 B1

PDFFull Text
Date of Patent:
Aug. 18, 2020

Filed:

Nov. 07, 2014

Piperidine or piperazine linked imidazole and triazole derivatives and methods of use

Applicants:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Craig A. Coburn, Novato, CA (US);

Milana M. Maletic, Summit, NJ (US);

Yunfu Luo, Shanghai, CN;

Zhiqi Qi, Shanghai, CN;

Tingting Yu, Shanghai, CN;

Richard Soll, Shanghai, CN;

Inventors:

Craig A. Coburn, Novato, CA (US);

Milana M. Maletic, Summit, NJ (US);

Yunfu Luo, Shanghai, CN;

Zhiqi Qi, Shanghai, CN;

Tingting Yu, Shanghai, CN;

Richard Soll, Shanghai, CN;

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Jeffrey P. Bergman

Catherine D. Fitch

Primary Examiner:

Brenda L Coleman

Int. Cl.
CPC ...
A61K 31/4178 (2006.01); A61K 31/4439 (2006.01); A61K 31/4436 (2006.01); A61K 31/443 (2006.01); A61K 31/551 (2006.01); A61K 31/541 (2006.01); A61K 31/5377 (2006.01); A61K 31/496 (2006.01); C07D 401/06 (2006.01); C07D 401/14 (2006.01); C07D 401/04 (2006.01); C07D 403/06 (2006.01); C07D 403/14 (2006.01); C07D 409/06 (2006.01); C07D 413/04 (2006.01); C07D 417/04 (2006.01); A61K 45/06 (2006.01); A61K 31/454 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 249/08 (2006.01); C07D 233/61 (2006.01); A61P 31/18 (2006.01); C07D 213/14 (2006.01); C07D 471/04 (2006.01); A61K 31/4545 (2006.01); C07D 471/10 (2006.01);
U.S. Cl.
CPC ...
C07D 401/06 (2013.01); A61K 31/4178 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61K 31/496 (2013.01); A61K 31/541 (2013.01); A61K 31/551 (2013.01); A61K 45/06 (2013.01); A61P 31/18 (2018.01); C07D 213/14 (2013.01); C07D 233/61 (2013.01); C07D 249/08 (2013.01); C07D 401/14 (2013.01); C07D 403/06 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 409/06 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 471/10 (2013.01);
Abstract

The present invention relates to piperidine or piperazine linked imidazole and triazole derivatives, compositions comprising said compounds, alone or in combination with other drugs, and methods of using the compounds for improving the pharmacokinetics of a drug. The compounds of the invention are useful in human and veterinary medicine for inhibiting CYP3A4 and for improving the pharmacokinetics of a therapeutic compound that is metabolized by CYP3A4.

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