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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10745364 B1

PDFFull Text
Date of Patent:
Aug. 18, 2020

Filed:

Feb. 08, 2019

Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of rorgamma activity and the treatment of disease

Applicants:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Lycera Corporation, Ann Arbor, MI (US);

Inventors:

Thomas D. Aicher, Ann Arbor, MI (US);

Chad A. VanHuis, Hartland, MI (US);

William D. Thomas, San Jose, CA (US);

John K. MacLean, Brookline, MA (US);

Brian M. Andresen, Boston, MA (US);

Kenneth J. Barr, Boston, MA (US);

Corey E. Bienstock, Natick, MA (US);

Neville J. Anthony, Northborough, MA (US);

Matthew Daniels, Somerville, MA (US);

Kun Liu, Needham, MA (US);

Yuan Liu, Billerica, MA (US);

Catherine M. White, Boston, MA (US);

Blair T. Lapointe, Brookline, MA (US);

Nunzio Sciammetta, Boston, MA (US);

Vladimir Simov, Boston, MA (US);

Assignees:

Lycera Corporation, Ann Arbor, MI (US);

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorney:

Dechert LLP

Primary Examiner:

Kahsay Habte

Int. Cl.
CPC ...
C07D 265/36 (2006.01); C07D 413/14 (2006.01); C07D 215/58 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 413/04 (2006.01); C07D 471/04 (2006.01); A61K 31/4375 (2006.01); A61K 31/47 (2006.01); A61K 31/4709 (2006.01); A61K 31/538 (2006.01); A61K 45/06 (2006.01); C07D 413/06 (2006.01); C07D 413/12 (2006.01); C07D 417/06 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
C07D 265/36 (2013.01); A61K 31/4375 (2013.01); A61K 31/47 (2013.01); A61K 31/4709 (2013.01); A61K 31/538 (2013.01); A61K 45/06 (2013.01); C07D 215/58 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 413/04 (2013.01); C07D 413/06 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/06 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); Y02A 50/409 (2018.01);
Abstract

The invention provides certain bicylic heterocyclic compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X, X, R, R, R, R4, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.

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