The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 18, 2020
Filed:
Apr. 12, 2019
The Regents of the University of California, Oakland, CA (US);
Yu-Hwa Lo, San Diego, CA (US);
Tony Minghung Yen, San Ramon, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
Disclosed are methods, devices and systems to cause differential evaporation of micro-droplets in a scalable fashion. In some embodiments, an attenuated laser is used to focus an attenuated laser power to the center of an aqueous solution droplet, producing a differential evaporative flux profile that is peaked at the droplet apex. The laser-induced differential evaporation described herein is a breakthrough in the enrichment and focused deposition of water-soluble molecules such as nucleic acids, proteins, inks, and other small molecules. Disclosed is a general solution to remove the 'coffee-ring effect', ubiquitous in the drying process of aqueous droplets that causes many adverse outcomes. The disclosed techniques enable new paradigms in liquid biopsy combinational analysis, microarray fabrication, and ink-jet printing.