The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 18, 2020

Filed:

Aug. 19, 2015
Applicants:

Shibuya Corporation, Kanazawa-shi, Ishikawa, JP;

Yamaguchi University, Yamaguchi-shi, Yamaguchi, JP;

Inventors:

Isao Sakaida, Ube, JP;

Shuji Terai, Niigata, JP;

Taro Takami, Ube, JP;

Koichi Fujisawa, Ube, JP;

Naoki Yamamoto, Ube, JP;

Kenji Yoneda, Kanazawa, JP;

Assignees:

YAMAGUCHI UNIVERSITY, Yamaguchi-shi, Yamaguchi, JP;

SHIBUYA CORPORATION, Kanazawa-shi, Ishikawa, unknown;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/28 (2015.01); C12Q 1/48 (2006.01); C12N 5/0775 (2010.01); G01N 33/50 (2006.01); A61K 45/00 (2006.01); C12Q 1/04 (2006.01); A61K 35/12 (2015.01);
U.S. Cl.
CPC ...
A61K 35/28 (2013.01); A61K 35/12 (2013.01); A61K 45/00 (2013.01); C12N 5/0663 (2013.01); C12Q 1/04 (2013.01); C12Q 1/48 (2013.01); C12Q 1/485 (2013.01); C12Y 207/04003 (2013.01); G01N 33/5005 (2013.01); C12N 2503/00 (2013.01); G01N 2333/91235 (2013.01);
Abstract

A method for evaluating the activity level of mesenchymal stem cells, and a method for culturing mesenchymal stem cells using the evaluation method in the field of culturing mesenchymal stem cells for regenerative medicine, and further, a method for producing a therapeutic agent for liver dysfunction and a therapeutic agent for liver dysfunction. This method for evaluating mesenchymal stem cell activity has an assay step for assaying the amount of adenylate kinase 4 (AK4) in the mesenchymal stem cells; and a determination step for determining the activity level of the mesenchymal stem cells from the assayed amount of adenylate kinase 4.


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