The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 18, 2020

Filed:

Sep. 12, 2017
Applicant:

Alar Pharmaceuticals, Inc., Taipei, TW;

Inventors:

Tong-Ho Lin, Taipei, TW;

Yung-Shun Wen, Taipei, TW;

Jui-Wei Liang, Taipei, TW;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/485 (2006.01); A61K 47/14 (2017.01); A61K 47/10 (2017.01); A61K 47/20 (2006.01); A61K 47/22 (2006.01); A61K 9/00 (2006.01); A61P 25/04 (2006.01); A61P 25/24 (2006.01); A61P 25/36 (2006.01);
U.S. Cl.
CPC ...
A61K 31/485 (2013.01); A61K 9/0019 (2013.01); A61K 47/10 (2013.01); A61K 47/14 (2013.01); A61K 47/20 (2013.01); A61K 47/22 (2013.01); A61P 25/04 (2018.01); A61P 25/24 (2018.01); A61P 25/36 (2018.01);
Abstract

An injectable pharmaceutical composition includes a solution of 3-acyl-buprenorphine, or a pharmaceutically acceptable salt thereof, in a biocompatible organic solvent, wherein the injectable pharmaceutical composition exhibits a steady release profile lasting over one week when injected into a patient. The acyl group is an alkylcarbonyl group, and an alkyl portion of the alkylcarbonyl group is a straight-chain, branched-chain, having 1-20 carbon atoms. The biocompatible organic solvent is N-methyl-2-pyrrolidone, ethyl acetate, ethanol, butanol, 2-butanol, isobutanol, ispropanol, glycerin, benzyl benzoate, dimethyl sulfoxide, N,N-dimethylacetamide, propylene glycol, dimethyl glycol, benzyl alcohol, or a combination of two or more thereof.


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