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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10744127 B1

PDFFull Text
Date of Patent:
Aug. 18, 2020

Filed:

Apr. 05, 2017

Mdr-reversing 8-hydroxy-quinoline derivatives

Applicant:

Magyar Tudományos Akadémia Természettudományi Kutatóközpont, Budapest, HU;

Inventors:

Gergely Szakács, Budapest, HU;

Tibor Soós, Budapest, HU;

Roberta Ferenczi-Palkó, Budapest, HU;

András Füredi, Budapest, HU;

Szilárd Tóth, Jászapáti, HU;

Dóra Türk, Budapest, HU;

Veronika Pape, Unna, DE;

Ferenc Fülöp, Szeged, HU;

István Szatmári, Szeged, HU;

György Dormán, Piliscsaba, HU;

Assignee:

Magyar Tudományos Akadémia Természettudományi Kutatóközpont, Budapest, HU;

Attorney:

Jason D. Voight

Primary Examiner:

Jeffrey H Murray

Int. Cl.
CPC ...
A61K 31/4709 (2006.01); C07D 215/38 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 417/12 (2006.01); C07D 471/04 (2006.01); C07D 495/04 (2006.01); A61K 45/06 (2006.01); A61K 31/47 (2006.01); C07D 215/36 (2006.01); C07D 401/14 (2006.01); A61P 35/04 (2006.01); A61K 31/4704 (2006.01); A61K 31/4725 (2006.01); A61K 31/498 (2006.01); C07D 215/28 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4709 (2013.01); A61K 31/47 (2013.01); A61K 31/4704 (2013.01); A61K 31/4725 (2013.01); A61K 31/498 (2013.01); A61K 45/06 (2013.01); A61P 35/04 (2018.01); C07D 215/28 (2013.01); C07D 215/36 (2013.01); C07D 215/38 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07D 495/04 (2013.01);
Abstract

The present invention is related to 8-hydroxy-quinoline derivatives having multidrug-resistance reversing activity with improved selectivity and increased cytotoxicity towards multidrug-resistant cancer cells, preparation thereof and use of the same in the treatment of cancer, especially multidrug-resistant variants thereof.

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