The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2020
Filed:
Jul. 08, 2016
Chu DE Nice, Nice, FR;
Centre National DE LA Recherche Scientifique—cnrs, Paris, FR;
Université DE Nice Sophia Antipolis, Nice, FR;
Vincent Louis Marie Esnault, Nice, FR;
Barbara Polski, La Trinité, FR;
Gérard Jean Frantz Lambeau, Cabris, FR;
Guillaume Dolla, Valbonne, FR;
Université de Nice Sophia Antipolis, Nice, FR;
Centre National de la Recherche Scientifique (CNRS), Paris, FR;
CHU de Nice, Nice, FR;
Abstract
Disclosed is a method for assessing the prognosis of idiopathic membranous nephropathy in a body fluid sample from a human subject, based on profiling PLA2R1 epitopes recognized by autoantibodies in the sample. The method further relates to analysis of PLA2R1 epitope spreading amongst three PLA2R1 domains (Cys R, CTLD1 and CTLD7) that are recognized by anti-PLA2R1 autoantibodies, two of which (CTLD1 and CTLD7) are more closely associated with active idiopathic membranous nephropathy and likely linked by a mechanism of epitope spreading.