The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2020
Filed:
Jul. 11, 2014
Applicant:
Cedars-sinai Medical Center, Los Angeles, CA (US);
Inventors:
Xiaojiang Cui, Arcadia, CA (US);
Sareen Dhruv, Porter Ranch, CA (US);
Loren A. Ornelas, Los Angeles, CA (US);
Assignee:
Cedars-Sinai Medical Center, Los Angeles, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/85 (2006.01); C12N 5/071 (2010.01); C12N 5/10 (2006.01); C12N 5/074 (2010.01);
U.S. Cl.
CPC ...
C12N 15/85 (2013.01); C12N 5/0696 (2013.01); C12N 15/8509 (2013.01); C12N 2501/115 (2013.01); C12N 2501/235 (2013.01); C12N 2501/415 (2013.01); C12N 2501/602 (2013.01); C12N 2501/603 (2013.01); C12N 2501/604 (2013.01); C12N 2501/608 (2013.01); C12N 2501/727 (2013.01); C12N 2506/09 (2013.01); C12N 2510/00 (2013.01);
Abstract
Described herein are reprogramming techniques allowing for production of mammary-derived iPSCs ('m-iPSCs'). The m-iPSCs described herein exhibit all the hallmarks of stem cell identity including round cluster, bright colony morphology, clonal expansion, and pluripotent marker expression (alkaline phosphatase expression, Oct-4, nanog, etc.) Further refined techniques allow for generation of m-iPSCs under essentially defined conditions.