The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2020
Filed:
Sep. 26, 2017
Applicant:
Northwestern University, Evanston, IL (US);
Inventors:
Melina R. Kibbe, Chicago, IL (US);
Samuel I. Stupp, Chicago, IL (US);
Assignee:
Other;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/64 (2006.01); A61K 47/64 (2017.01); A61K 45/06 (2006.01); A61K 9/00 (2006.01); A61K 38/48 (2006.01); A61K 9/70 (2006.01); A61K 47/54 (2017.01); A61K 47/69 (2017.01);
U.S. Cl.
CPC ...
C12N 9/6437 (2013.01); A61K 9/0019 (2013.01); A61K 9/70 (2013.01); A61K 38/4833 (2013.01); A61K 45/06 (2013.01); A61K 47/542 (2017.08); A61K 47/64 (2017.08); A61K 47/69 (2017.08); C12Y 304/21005 (2013.01); C12Y 304/21006 (2013.01); C12Y 304/21021 (2013.01);
Abstract
Provided herein are tissue factor (TF)-targeted nanofibers and methods of treating hemorrhage in a subject therewith. In particular, peptide amphiphiles (PAs) are provided that comprise a TF-targeting peptide sequence and self-assemble under aqueous conditions into PA nanofibers displaying the TF-targeting sequence on the exterior of the nanofiber.