The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2020
Filed:
Mar. 22, 2017
Applicant:
Cellectis S.a., Paris, FR;
Inventors:
George Silva, Le Plessis-Trevise, FR;
Marine Beurdeley, Paris, FR;
Assignee:
CELLECTIS, Paris, FR;
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/22 (2006.01); C07K 14/47 (2006.01); C12N 9/16 (2006.01); C12N 15/90 (2006.01); C12N 15/82 (2006.01); C07K 14/195 (2006.01);
U.S. Cl.
CPC ...
C12N 9/22 (2013.01); C07K 14/195 (2013.01); C12N 15/8213 (2013.01); C12N 15/907 (2013.01); C07K 2319/80 (2013.01);
Abstract
The present invention relates to a method to cleave target nucleic acid sequence by the catalytic domain of a GIY-YIG homing endonucleases I-TevI. More precisely, the invention relates to the deciphering of new preferential I-TevI cleavage sites for efficient and specific cleavage activity. The invention concerns a method for the generation of TevI specific chimeric endonucleases to target nucleic acid sequence including such cleavage sites and methods of using same for gene editing.