The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2020
Filed:
Jul. 04, 2017
Applicant:
National Research Council of Canada, Ottawa, CA;
Inventors:
Danica Stanimirovic, Ottawa, CA;
Kristin Kemmerich, Ottawa, CA;
Yves Durocher, Montréal, CA;
Traian Sulea, Kirkland, CA;
Assignee:
National Research Council of Canada, Ottawa, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
C07K 16/28 (2013.01); A61K 47/6849 (2017.08); C07K 2317/22 (2013.01); C07K 2317/24 (2013.01); C07K 2317/35 (2013.01); C07K 2317/52 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/569 (2013.01); C07K 2317/64 (2013.01); C07K 2317/70 (2013.01); C07K 2317/94 (2013.01); C07K 2319/30 (2013.01);
Abstract
The present invention relates to antibodies and fragments thereof derived by humanization of an existing antibody, and methods of making them. The humanized antibodies of the present invention show enhanced binding to the brain endothelial antigen, improved transmigration across the blood-brain barrier, and increased thermal stability relative to the parent non-humanized antibody.