The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2020
Filed:
Sep. 18, 2018
Pfizer Inc., New York, NY (US);
The Regents of the University of California, Oakland, CA (US);
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Isaac J. Rondon, San Francisco, CA (US);
Natasha Crellin, San Carlos, CA (US);
Paul Bessette, San Francisco, CA (US);
Eleonora Trotta, San Francisco, CA (US);
Jeffrey A. Bluestone, San Francisco, CA (US);
Lauren K. Ely, Palo Alto, CA (US);
Kenan C. Garcia, Menlo Park, CA (US);
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);
PFIZER INC., New York, NY (US);
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, Stanford, CA (US);
Abstract
The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Rα and IL-2Rβ. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.