The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 11, 2020

Filed:

Nov. 03, 2015
Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

Ji Zheng, Warrington, PA (US);

Jue Wang, Bridgewater, NJ (US);

Assignee:

BRISTOL-MYERS SQUIBB COMPANY, Princeton, NJ (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 1/22 (2006.01); C07K 1/36 (2006.01); C07K 16/06 (2006.01); C07K 1/18 (2006.01); C07K 1/32 (2006.01);
U.S. Cl.
CPC ...
C07K 1/32 (2013.01); C07K 1/18 (2013.01); C07K 1/22 (2013.01); C07K 1/36 (2013.01); C07K 16/065 (2013.01);
Abstract

In certain embodiments, the invention provides a method of purifying a protein of interest from a mixture which comprises the protein of interest and one or more contaminants, comprising: a) subjecting the mixture to a first chromatography step; b) recovering the protein of interest in an elution solution; c) adding caprylic acid to the elution solution to form a contaminant precipitate; d) removing the contaminant precipitate from the elution solution; and e) subjecting the post-precipitated elution solution to a second chromatography column, thereby purifying the protein of interest.


Find Patent Forward Citations

Zheng, Ji. (2020). Use of caprylic acid precipitation for protein purification (U.S. Patent No. 10738078). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10738078

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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