The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2020
Filed:
Dec. 12, 2016
Applicants:
R-pharm Joint Stock Company (R-pharm, Jsc), Moscow, RU;
Alexey Evgenievich Repik, Yaroslavl, RU;
Inventors:
Alexandre Vasilievich Ivachtchenko, Hallandale Beach, FL (US);
Alexey Evgenievich Repik, Yaroslavl, RU;
Vasily Gennadievich Ignatiev, Moscow, RU;
Mikhail Airatovich Chafeev, Moscow, RU;
Assignee:
R-PHARM JOINT STOCK COMPANY (R-PHARM, JSC), Moscow, RU;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/519 (2006.01); C07D 471/04 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61P 35/00 (2018.01); A61K 31/519 (2013.01); C07B 2200/13 (2013.01);
Abstract
Novel MEK1, MEK2 and MEK1/2 inhibitors which have lower toxicity in long-term dosage, including the novel compound N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]-phenyl}-cyclopropanecarboxamide dimethyl sulfoxide solvate according to formula 1: