The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 11, 2020

Filed:

Mar. 31, 2017
Applicant:

Vertex Pharmaceuticals Incorporated, Boston, MA (US);

Inventors:

Brian Bear, Carlsbad, CA (US);

Jeremy Clemens, San Diego, CA (US);

Thomas Cleveland, San Diego, CA (US);

Timothy Richard Coon, Carlsbad, CA (US);

Peter Diederik Jan Grootenhuis, San Diego, CA (US);

Bryan A. Frieman, La Jolla, CA (US);

Sara S. Hadida Ruah, Del Mar, CA (US);

Haripada Khatuya, San Diego, CA (US);

Paul J. Krenitsky, San Diego, CA (US);

Mark Thomas Miller, San Diego, CA (US);

Alina Silina, San Diego, CA (US);

Johnny Uy, San Diego, CA (US);

Jinglan Zhou, San Diego, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/14 (2006.01); C07D 213/82 (2006.01); A61P 11/00 (2006.01); C07D 401/12 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61P 11/00 (2018.01); C07D 213/82 (2013.01); C07D 401/12 (2013.01); C07D 471/04 (2013.01);
Abstract

The present disclosure features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R, R, W, X, Z, n, p, and Rings A and B are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present disclosure also features pharmaceutical compositions, method of treating, and kits thereof.


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