The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2020
Filed:
Dec. 23, 2015
Applicant:
Proteostasis Therapeutics, Inc., Cambridge, MA (US);
Inventors:
Cecilia M. Bastos, South Grafton, MA (US);
Benito Munoz, Newtonville, MA (US);
Bradley Tait, Malden, MA (US);
Assignee:
Proteostasis Therapeutics, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 231/14 (2006.01); C07D 249/06 (2006.01); C07D 413/12 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); A61P 11/00 (2006.01); A61K 31/415 (2006.01); A61K 31/4155 (2006.01); A61K 31/4178 (2006.01); A61K 31/5377 (2006.01); A61K 45/06 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C07D 231/14 (2013.01); A61K 31/415 (2013.01); A61K 31/4155 (2013.01); A61K 31/4178 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); A61P 11/00 (2018.01); C07D 249/06 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 413/12 (2013.01); G01N 33/6872 (2013.01); G01N 2800/382 (2013.01);
Abstract
The present disclosure is based, in part, on the discovery that disclosed compounds such as those having Formula (IVa), (Va), (IV), or (V) can increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells.