The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2020
Filed:
Nov. 24, 2017
Universiteit Antwerpen, Antwerp, BE;
Universitair Ziekenhuis Antwerpen, Edegem, BE;
Koen Augustyns, Antwerp, BE;
Matthias Cleenewerck, Antwerp, BE;
Guido R. Y. De Meyer, Antwerp, BE;
Jurgen Joossens, Antwerp, BE;
Ammar Kurdi, Antwerp, BE;
Pieter Van Der Veken, Antwerp, BE;
Christel Vangestel, Edegem, BE;
Sigrid Stroobants, Edegem, BE;
Wim Martinet, Antwerp, BE;
UNIVERSITAIR ZIEKENHUIS ANTWERPEN, Edegem, BE;
UNIVERSITEIT ANTWERPEN, Antwerp, BE;
Abstract
The present invention relates to compounds having a benzotropolone core, and compositions containing said compounds acting as ATG4B inhibitors, thereby inhibiting autophagy. Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine, in particular for the treatment of cell proliferative disorders, such as cancer. Halogenated benzotropolones described here are of formula