The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 11, 2020

Filed:

Aug. 07, 2017
Applicant:

Li-cor, Inc., Lincoln, NE (US);

Inventors:

Michael D. Furtaw, Lincoln, NE (US);

Donald T. Lamb, Lincoln, NE (US);

Lyle R. Middendorf, Lincoln, NE (US);

Assignee:

LI-COR, INC., Lincoln, NE (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 27/447 (2006.01); B01L 3/00 (2006.01); B01L 3/02 (2006.01); G01N 1/40 (2006.01);
U.S. Cl.
CPC ...
B01L 3/502753 (2013.01); B01L 3/0268 (2013.01); B01L 3/50273 (2013.01); G01N 1/405 (2013.01); G01N 27/44739 (2013.01); G01N 27/44756 (2013.01); G01N 27/44791 (2013.01); B01L 3/5027 (2013.01); B01L 3/502776 (2013.01); B01L 2200/0631 (2013.01); B01L 2200/0636 (2013.01); B01L 2300/06 (2013.01); B01L 2300/069 (2013.01); B01L 2300/0681 (2013.01); B01L 2300/0867 (2013.01); B01L 2400/0415 (2013.01); B01L 2400/0421 (2013.01); B01L 2400/0487 (2013.01);
Abstract

Devices and methods are provided for the separation and dispensing of material using a microfluidic separation column connected via an exit channel to one or more sheath flow channels. The flow of separated material through the separation column is at least partially driven by a voltage potential between a first electrode within the separation column and a terminating electrode within at least one of the sheath flow channels. The separation column, exit channel, sheath flow channels, and electrodes are all within a single monolithic chip. The presence of an on-chip terminating electrode allows for separated material to be entrained in the sheath fluids and ejected onto a surface that can be non-conductive. The presence of multiple sheath flows allows for sheath flow fluids to have different compositions from one another, while reducing the occurrence of sheath flow fluids entering the separation column.


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