The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 11, 2020

Filed:

Aug. 12, 2015
Applicants:

Chengdu Southwest Jiaotong University Science and Technology Garden Management Co., Ltd., Sichuan, CN;

Chengdu Jiaoda Medical Science and Technology Company Limited, Chengdu, Sichuan, CN;

Inventors:

Zhilu Yang, Sichuan, CN;

Nan Huang, Sichuan, CN;

Jin Wang, Sichuan, CN;

Yajun Weng, Sichuan, CN;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61L 31/10 (2006.01); A61L 31/16 (2006.01); A61K 33/00 (2006.01); A61F 2/06 (2013.01); C09D 7/40 (2018.01); C09D 7/61 (2018.01); A61L 27/34 (2006.01); A61L 27/50 (2006.01); A61L 27/54 (2006.01); A61L 29/08 (2006.01); A61L 29/16 (2006.01); C09D 5/00 (2006.01); C09D 177/04 (2006.01); C09D 177/12 (2006.01); C08K 5/13 (2006.01); C08K 3/011 (2018.01); A61M 25/00 (2006.01); A61M 25/09 (2006.01); C08K 3/16 (2006.01);
U.S. Cl.
CPC ...
A61L 31/10 (2013.01); A61F 2/06 (2013.01); A61K 33/00 (2013.01); A61L 27/34 (2013.01); A61L 27/507 (2013.01); A61L 27/54 (2013.01); A61L 29/085 (2013.01); A61L 29/16 (2013.01); A61L 31/16 (2013.01); C09D 5/00 (2013.01); C09D 7/40 (2018.01); C09D 7/61 (2018.01); C09D 177/04 (2013.01); C09D 177/12 (2013.01); A61L 2300/114 (2013.01); A61L 2300/606 (2013.01); A61L 2420/02 (2013.01); A61M 2025/0046 (2013.01); A61M 2025/09133 (2013.01); C08K 3/011 (2018.01); C08K 3/16 (2013.01); C08K 5/13 (2013.01);
Abstract

Disclosed is a method for preparing a nitric oxide-generating adherent coating, comprising: preparing a buffer solution containing polyphenol compounds, organic selenium or sulfur compounds and soluble copper salts; then contacting a base material with the solution, and washing and drying to obtain a target product. The nitric oxide-generating material prepared by the method can be used for any medical device, such as an intravascular stent, or materials and any complex-shaped base material, and has the capability of scavenging free radicals and catalyzing RSNO to produce nitrogen monoxide, and also has a response function of reduced glutathione (GSH), an antimicrobial function and all the physiological functions possessed by nitrogen monoxide.


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