The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2020
Filed:
Jan. 22, 2016
Applicant:
Icahn School of Medicine AT Mount Sinai, New York, NY (US);
Inventors:
Peter Palese, New York, NY (US);
Adolfo Garcia-Sastre, New York, NY (US);
Florian Krammer, New York, NY (US);
Assignee:
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/145 (2006.01); A61K 39/12 (2006.01); C07K 14/005 (2006.01); C07K 14/11 (2006.01); C12N 7/04 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/145 (2013.01); A61K 39/12 (2013.01); C07K 14/005 (2013.01); C07K 14/11 (2013.01); C12N 7/04 (2013.01); A61K 2039/543 (2013.01); A61K 2039/575 (2013.01); C07K 2319/00 (2013.01); C12N 2760/16134 (2013.01); C12N 2760/16234 (2013.01);
Abstract
Provided herein are immunization regimens for inducing an immune response (e.g., an antibody response) against influenza virus. In specific aspects, the immunization regimens involve the administration of a chimeric hemagglutinin (HA), a headless HA or another influenza virus stem domain based construct (e.g., the HA stem domain or a fragment thereof) to a subject. In certain aspects, the immunization regimens also involve the administration of an influenza virus neuraminidase immunogen.