The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2020
Filed:
May. 07, 2013
Applicant:
Trustees of Tufts College, Medford, MA (US);
Inventors:
David L. Kaplan, Concord, MA (US);
Xiaoqin Wang, Winchester, MA (US);
Assignee:
Trustees of Tufts College, Medford, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/16 (2006.01); A61K 9/19 (2006.01); C07K 14/435 (2006.01); A61K 38/44 (2006.01); A61K 47/42 (2017.01); A61K 47/34 (2017.01); A61K 9/50 (2006.01); A61K 31/7076 (2006.01); A61K 9/127 (2006.01);
U.S. Cl.
CPC ...
A61K 38/44 (2013.01); A61K 9/16 (2013.01); A61K 9/1658 (2013.01); A61K 9/5052 (2013.01); A61K 31/7076 (2013.01); A61K 47/34 (2013.01); A61K 47/42 (2013.01); A61K 9/127 (2013.01); A61K 9/19 (2013.01);
Abstract
A method was developed to prepare silk fibroin microspheres using lipid vesicles as templates to efficiently load therapeutic agents in active form for controlled release. The lipids are subsequently removed through the use of a dehydration agent, such as methanol or sodium chloride, resulting in β-sheet structure dominant silk microsphere structures having about 2 μm in diameter. The therapeutic agent can be entrapped in the silk microspheres and used in pharmaceutical formulations for controlled-release treatments.