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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10736941 B1

PDFFull Text
Date of Patent:
Aug. 11, 2020

Filed:

May. 18, 2016

Cell membrane-permeating peptide

Applicant:

National University Corporation Kumamoto University, Kumamoto-shi, Kumamoto, JP;

Inventors:

Shingo Ito, Kumamoto, JP;

Sumio Ohtsuki, Kumamoto, JP;

Assignee:

NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY, Kumamoto, JP;

Attorney:

Hunton Andrews Kurth LLP

Primary Examiner:

James H Alstrum-Acevedo

Assistant Examiner:

Tara L Martinez

Int. Cl.
CPC ...
A61K 38/28 (2006.01); A61K 47/40 (2006.01); A61K 9/127 (2006.01); A61K 31/711 (2006.01); A61K 31/713 (2006.01); C07K 7/06 (2006.01); C12N 7/00 (2006.01); A61K 45/06 (2006.01); C07K 7/64 (2006.01); C07K 19/00 (2006.01); C12N 15/113 (2010.01); A61P 3/10 (2006.01);
U.S. Cl.
CPC ...
A61K 38/28 (2013.01); A61K 9/127 (2013.01); A61K 31/711 (2013.01); A61K 31/713 (2013.01); A61K 45/06 (2013.01); A61K 47/40 (2013.01); A61P 3/10 (2018.01); C07K 7/06 (2013.01); C07K 7/64 (2013.01); C07K 19/00 (2013.01); C12N 7/00 (2013.01); C12N 15/113 (2013.01); C12N 2795/14121 (2013.01); C12N 2795/14131 (2013.01);
Abstract

The present invention addresses to provide a novel membrane permeability-improving agent which can be applied to high molecular drugs. More specifically, the present invention addresses to provide: a drug carrier which can improve the absorption efficiency of a high molecular drug in the small intestine; and a membrane permeation-improving agent containing the carrier. According to the present invention, a cell membrane-permeating peptide can be provided, which comprises an amino acid sequence selected from the group consisting of the following amino acid sequences: DNPGN (SEQ ID NO: 1); SRPAF (SEQ ID NO: 2); NDPRN (SEQ ID NO: 3); and MSVAN (SEQ ID NO: 4). According to the present invention, a cell membrane-permeable composition can also be provided, which comprises the peptide and a biologically active substance.

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