The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2020
Filed:
Nov. 11, 2016
Applicant:
University of Massachusetts, Boston, MA (US);
Inventor:
Murugappan Muthukumar, Amherst, MA (US);
Assignee:
UNIVERSITY OF MASSACHUSETTS, Boston, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/197 (2006.01); A61K 31/4015 (2006.01); A61K 9/00 (2006.01); A61K 31/195 (2006.01); A61K 31/765 (2006.01); G02C 7/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/197 (2013.01); A61K 9/0048 (2013.01); A61K 31/195 (2013.01); A61K 31/4015 (2013.01); A61K 31/765 (2013.01); G02C 7/04 (2013.01);
Abstract
Described herein are methods of inhibiting or reversing the progression of cataract formation or presbyopia in an eye by administering a bifunctional molecule comprising a substituted or unsubstituted amine, succinimide, carboxylic acid, isocyanate, isothiocyanate, sulfonyl chloride, aldehyde, carbodiimide, acyl azide, anhydride, fluorobenzene, carbonate, N-hydroxysuccinimide ester, imidoester, epoxide or fluorophenyl ester covalently linked to a molecular bristle. Both presbyopia and cataracts are caused by aggregation of the soluble crystalline lens proteins called the crystallins.