The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 04, 2020

Filed:

May. 10, 2016
Applicant:

The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);

Inventors:

John Scott Mellors, Carrboro, NC (US);

Erin Anne Redman, Carrboro, NC (US);

John Michael Ramsey, Chapel Hill, NC (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
H01J 49/16 (2006.01); G01N 27/447 (2006.01); G01N 27/453 (2006.01); B01L 3/00 (2006.01); G01N 30/72 (2006.01);
U.S. Cl.
CPC ...
H01J 49/167 (2013.01); B01L 3/50273 (2013.01); G01N 27/44743 (2013.01); G01N 27/44791 (2013.01); B01L 2200/0605 (2013.01); B01L 2300/0816 (2013.01); B01L 2400/0421 (2013.01); B01L 2400/0487 (2013.01); B01L 2400/0694 (2013.01); G01N 30/7266 (2013.01); H01J 49/165 (2013.01);
Abstract

A pneumatic method, and associated apparatus, for injecting a discrete sample plug into the separation channel of an electrophoresis microchip () is disclosed. In a first step, pressurized gas () is applied to the sample () and background electrolyte () reservoirs such that the pressure is higher there than at the sample waste reservoir () to create a focused sample stream at the junction between the sample and separation channels. In a second step, the pressure at the sample reservoir () is reduced in order to pneumatically inject the sample plug into the separation channel. The waste reservoir () may be connected to a pressure reducing device (). The methods, systems and devices are particularly suitable for use with a mass spectrometer ().


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