The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 04, 2020

Filed:

May. 22, 2016
Applicants:

President and Fellows of Harvard College, Cambridge, MA (US);

Children's Medical Center Corporation, Boston, MA (US);

Inventors:

Donald E. Ingber, Boston, MA (US);

Abhishek Jain, Roslindale, MA (US);

Andries D. van der Meer, Enschede, NL;

Alan David Michelson, Boston, MA (US);

Andrew L. Frelinger, III, North Reading, MA (US);

Riccardo Barrile, Boston, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/50 (2006.01); B01L 3/00 (2006.01); G01N 33/86 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5064 (2013.01); B01L 3/5027 (2013.01); G01N 33/86 (2013.01); G01N 2800/226 (2013.01);
Abstract

A method is directed to determining a thrombosis function and includes flowing a fluid sample over a surface having a fixed endothelial cell monolayer. The method further includes stimulating the fixed endothelial cell monolayer to induce formation of a clot, the clot being formed via interaction between the fixed endothelial cell monolayer and the fluid sample. In response to the clot formation, the method further includes determining a thrombosis function associated with the fluid sample and the fixed endothelial cell monolayer.


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