The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 04, 2020
Filed:
Nov. 11, 2015
Applicant:
Battelle Memorial Institute, Richland, WA (US);
Inventors:
Stephen R. Lindemann, Lafayette, IN (US);
Aaron T. Wright, Richland, WA (US);
Assignee:
BATTELLE MEMORIAL INSTITUTE, Richland, WA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6809 (2018.01); C12N 15/10 (2006.01); C12Q 1/6816 (2018.01); C12Q 1/6869 (2018.01);
U.S. Cl.
CPC ...
C12Q 1/6809 (2013.01); C12N 15/10 (2013.01); C12Q 1/6816 (2013.01); C12Q 1/6869 (2013.01); C12Q 2523/101 (2013.01); C12Q 2523/319 (2013.01);
Abstract
Methods and systems for identifying binding sites in macromolecules using small molecule mimics of naturally occurring molecules is disclosed. A reactive probe is provided that mimics small molecule cofactors. A target macromolecule is irreversibly bound to the probe in vivo to selectively pull down or precipitate probe-bound macromolecules. The macromolecules may be, but are not limited to, DNA, RNA, and proteins.