The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 04, 2020
Filed:
Oct. 10, 2016
Assistance Publique-hopitaux DE Paris, Paris, FR;
Imagine Institut Des Maladies Genetiques Necker Enfants Malades, Paris, FR;
Universite Paris Descartes, Paris, FR;
Institut National DE LA Sante ET DE LA Recherche Medicale (Inserm), Paris, FR;
Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;
Sylvia Sanquer, Sevres, FR;
Anne-Claire Boschat, Choisy-le-roi, FR;
Sylvain Latour, Vitry sur Seine, FR;
Emmanuel Martin, Paris, FR;
Robert Barouki, Sevres, FR;
Abstract
The present invention relates to a method for detecting or quantifying CTP in a cell sample comprising at least two nucleotide triphosphates by cationic ion pairing chromatography coupled to mass spectrometry, to a method for detecting or quantifying CTP synthase activity based on the method for detecting or quantifying CTP, and to their use in methods for screening potential immunosuppressive or anti-cancer compounds and in methods for determining the appropriate dose of an immunosuppressive or anti-cancer compound inhibiting CTP synthase activity for a treated subject.