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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10730983 B1

PDFFull Text
Date of Patent:
Aug. 04, 2020

Filed:

Jun. 13, 2017

Biocompatible coatings and hydrogels for reducing foreign body response and fibrosis

Applicants:

Massachusetts Institute of Technology, Cambridge, MA (US);

The Children's Medical Center Corporation, Boston, MA (US);

Inventors:

Omid Veiseh, Cambridge, MA (US);

Volkan Yesilyurt, Watertown, MA (US);

Arturo Vegas, Belmont, MA (US);

Joshua Doloff, Quincy, MA (US);

Daniel G. Anderson, Framingham, MA (US);

Robert S. Langer, Newton, MA (US);

Assignees:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA (US);

THE CHILDREN'S MEDICAL CENTER CORPORATION, Boston, MA (US);

Attorney:

Pabst Patent Group LLP

Primary Examiner:

Kyle A Purdy

Int. Cl.
CPC ...
C08F 230/02 (2006.01); A61L 29/08 (2006.01); A61L 27/26 (2006.01); A61L 27/52 (2006.01); A61L 27/34 (2006.01); A61L 27/38 (2006.01); A61L 27/54 (2006.01); A61K 35/12 (2015.01); A61K 9/50 (2006.01); A61L 29/04 (2006.01); A61L 31/10 (2006.01); A61L 31/04 (2006.01); A61L 27/56 (2006.01); A61L 29/16 (2006.01); A61L 31/16 (2006.01); C08F 220/38 (2006.01); C08F 30/02 (2006.01); C08F 20/38 (2006.01); A61B 5/145 (2006.01);
U.S. Cl.
CPC ...
C08F 230/02 (2013.01); A61B 5/14532 (2013.01); A61K 9/5026 (2013.01); A61K 9/5036 (2013.01); A61K 35/12 (2013.01); A61L 27/34 (2013.01); A61L 27/38 (2013.01); A61L 27/52 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); A61L 29/041 (2013.01); A61L 29/085 (2013.01); A61L 29/16 (2013.01); A61L 31/048 (2013.01); A61L 31/10 (2013.01); A61L 31/16 (2013.01); C08F 20/38 (2013.01); C08F 30/02 (2013.01); C08F 220/38 (2013.01); A61B 2560/0223 (2013.01); A61L 2300/404 (2013.01); A61L 2400/18 (2013.01); A61L 2420/02 (2013.01); A61L 2420/06 (2013.01); C08F 220/387 (2020.02); C08F 2438/03 (2013.01); C08F 2800/20 (2013.01);
Abstract

Zwitterionic polymers or biocompatible polymers with improved properties for cell encapsulation, coating of devices, or a combination thereof are described. The biocompatible polymer contains a zwitterionic monomer, a monomer with a reactive side chain, and optionally another hydrophobic monomer or a neutral hydrophilic monomer. The zwitterionic polymers are cross-linked with a cross-linker via covalent bond to form a zwitterionic hydrogel in the presence of cells. Also provided, are methods of making and using the zwitterionic polymers.

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