The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 04, 2020

Filed:

Jul. 14, 2017
Applicants:

Miltenyi Biotec Gmbh, Bergisch Gladbach, DE;

Stefan Dübel, Braunschweig, DE;

Inventors:

Stefan Dübel, Braunschweig, DE;

Sarah-Jane Kellmann, Gummersbach, DE;

Holger Thie, Biberach an der Riss, DE;

Assignee:

Miltenyi Biotech B.V. & Co. KG, Bergisch Gladbach, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/47 (2006.01); C07K 16/40 (2006.01); C12N 9/12 (2006.01);
U.S. Cl.
CPC ...
C07K 14/4728 (2013.01); C07K 16/40 (2013.01); C12N 9/12 (2013.01); C12Y 207/11018 (2013.01); C07K 2317/56 (2013.01); C07K 2317/622 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01);
Abstract

The present invention provides a composition comprising i) a polypeptide comprising calmodulin and two immunoglobulin superfamily domains, wherein said two immunoglobulin superfamily domains are linked via said calmodulin; ii) a calmodulin binding molecule; iii) ions binding to the Cabinding site of calmodulin; wherein the binding of said calmodulin-binding molecule and of said ions to said Cabinding site of calmodulin affects the binding of said polypeptide to an antigen to be bound by said polypeptide. The calmodulin may be a permutated calmodulin. A method for affecting the binding of a polypeptide for an antigen using said composition is also disclosed.


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