The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 04, 2020

Filed:

Dec. 12, 2017
Applicant:

Hangzhou Innogate Pharma Co., Ltd., Hangzhou, Zhejiang, CN;

Inventors:

Hancheng Zhang, Zhejiang, CN;

Shifeng Liu, Zhejiang, CN;

Xiangyang Ye, Zhejiang, CN;

Assignee:

Hangzhou Innogate Pharma Co., Ltd., Hangzhou, Zhejiang, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 498/04 (2006.01); C07D 471/04 (2006.01); A61P 1/16 (2006.01); A61P 35/00 (2006.01); A61K 31/5383 (2006.01); C07D 519/00 (2006.01); A61P 11/00 (2006.01);
U.S. Cl.
CPC ...
C07D 498/04 (2013.01); A61K 31/5383 (2013.01); A61P 1/16 (2018.01); A61P 11/00 (2018.01); A61P 35/00 (2018.01); C07D 471/04 (2013.01); C07D 519/00 (2013.01); Y02P 20/55 (2015.11);
Abstract

A class of compounds containing a tricyclic heteroaryl group is provided. Specifically, a compound of the structure represented by the following formula (I) (each group is as defined in the specification), a pharmaceutical composition containing the compound of the formula (I), and their isotope derivatives, chiral isomers, allosterics, different salts, prodrugs, preparations, etc, are provided. It can effectively inhibit protein kinases (such as EGFR, FAK, SYK, FLT-3, Axl, CDK, JAK, etc.), thereby treating various tumors, non-alcoholic liver disease (NASH), pulmonary fibrosis (IPF), and related variety of diseases.


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