The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 04, 2020

Filed:

Nov. 21, 2016
Applicant:

Yunnan Institute of Materia Medica, Kunming, CN;

Inventors:

Jingkun Wang, Kunming, CN;

Zhaoyun Zhu, Kunming, CN;

He Song, Kunming, CN;

Min Sun, Kunming, CN;

Tao Cui, Kunming, CN;

Zeren Wang, Kunming, CN;

Zhi Yang, Kunming, CN;

Min Su, Kunming, CN;

Hongbin Liu, Kunming, CN;

Bing Shi, Kunming, CN;

Yong Mao, Kunming, CN;

Huilang Liu, Kunming, CN;

Zeqian Li, Kunming, CN;

Chunmei Zhao, Kunming, CN;

Mei Su, Kunming, CN;

Fang Yuan, Kunming, CN;

Tiancai Zhang, Kunming, CN;

Yong Liu, Kunming, CN;

Kuanren Zhang, Kunming, CN;

Yunlin Wei, Kunming, CN;

Yuehai Shen, Kunming, CN;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/10 (2006.01); A61P 25/24 (2006.01); A61P 1/04 (2006.01); A61P 9/10 (2006.01); A61P 29/00 (2006.01); A61K 31/496 (2006.01); A61P 25/04 (2006.01);
U.S. Cl.
CPC ...
C07D 401/10 (2013.01); A61K 31/496 (2013.01); A61P 1/04 (2018.01); A61P 9/10 (2018.01); A61P 25/04 (2018.01); A61P 25/24 (2018.01); A61P 29/00 (2018.01); C07B 2200/13 (2013.01);
Abstract

The application discloses five polymorph forms B, P, F, J, O of (4-((R)-((2S,5R)-4-(3-fluorobenzyl)-(2,5-dimethylpiperazine-1-yl)(3-hydroxyphenyl)methyl)phenyl)(4-methylpiperidine-1-yl)methanone dihydrochloride, preparation methods thereof and application thereof in the manufacture of a medicament for preventing or treating a mood disorder or a disease related to a δ opioid receptor.


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