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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10730842 B1

PDFFull Text
Date of Patent:
Aug. 04, 2020

Filed:

Sep. 02, 2016

Small molecule inhibitors of dyrk1a and uses thereof

Applicant:

Arizona Board of Regents on Behalf of the University of Arizona, Tucson, AZ (US);

Inventors:

Christopher Hulme, Tucson, AZ (US);

Travis Dunckley, Phoenix, AZ (US);

Yeng-Jeng Shaw, Tucson, AZ (US);

Assignees:

ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, Tucson, AZ (US);

THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE, Phoenix, AZ (US);

Attorneys:

Casimir Jones, SC

Robert Goetz

Primary Examiner:

Kortney L Klinkel

Assistant Examiner:

Tori Strong

Int. Cl.
CPC ...
C07D 235/06 (2006.01); A61K 31/4184 (2006.01); A61K 31/4439 (2006.01); A61K 31/4545 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 45/06 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 405/04 (2006.01); C07D 405/14 (2006.01); C07D 409/04 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 235/06 (2013.01); A61K 31/4184 (2013.01); A61K 31/4439 (2013.01); A61K 31/4545 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 405/04 (2013.01); C07D 405/14 (2013.01); C07D 409/04 (2013.01); C07D 471/04 (2013.01);
Abstract

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a benzimidazole or imidazopyridine structure which function as inhibitors of DYRK1A protein, and their use as therapeutics for the treatment of Alzheimer's disease, Down syndrome, glioblastoma, autoimmune diseases, inflammatory disorders (e.g., airway inflammation), and other diseases.

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